Dynamic ion pair behavior stabilizes single α-helices in proteins
نویسندگان
چکیده
منابع مشابه
Stable Single α-Helices Are Constant Force Springs in Proteins*
Single α-helix (SAH) domains are rich in charged residues (Arg, Lys, and Glu) and stable in solution over a wide range of pH and salt concentrations. They are found in many different proteins where they bridge two functional domains. To test the idea that their high stability might enable these proteins to resist unfolding along their length, the properties and unfolding behavior of the predict...
متن کاملCorrection: Distribution and evolution of stable single α-helices (SAH domains) in myosin motor proteins
[This corrects the article DOI: 10.1371/journal.pone.0174639.].
متن کاملDistribution and evolution of stable single α-helices (SAH domains) in myosin motor proteins
Stable single-alpha helices (SAHs) are versatile structural elements in many prokaryotic and eukaryotic proteins acting as semi-flexible linkers and constant force springs. This way SAH-domains function as part of the lever of many different myosins. Canonical myosin levers consist of one or several IQ-motifs to which light chains such as calmodulin bind. SAH-domains provide flexibility in leng...
متن کاملVibron-polaron in Α-helices. I. Single-vibron States
The vibron dynamics associated to amide-I vibrations in a 3D α-helix is described according to a generalized Davydov model. The helix is modeled by three spines of hydrogen-bonded peptide units linked via covalent bonds. To remove the intramolecular anharmonicity of each amide-I mode and to renormalized the vibron-phonon coupling, two unitary transformation have been applied to reach the dresse...
متن کاملLocal and macroscopic electrostatic interactions in single α-helices.
The noncovalent forces that stabilize protein structures are not fully understood. One way to address this is to study equilibria between unfolded states and α-helices in peptides. Electrostatic forces-which include interactions between side chains, the backbone and side chains, and side chains and the helix macrodipole-are believed to contribute to these equilibria. Here we probe these interac...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.006752